Combining Biomarkers with Risk Factors to Predict Coronary Artery Disease

Although cardiovascular risk factors such as increased age, hypertension, diabetes mellitus, smoking and dyslipidemia are well known, they do not accurately predict the risk of coronary artery disease. A Korean research group led by Sunsoo Cho1 evaluated whether adding additional biomarkers to these conventional risk factors would increase their ability to predict coronary artery disease.

This […]

By |January 1st, 2016|Cardio Vascular Disease|0 Comments

TIMP-1 and HER2 ECD as Biomarkers for Breast Cancer

Researchers are currently investigating tissue inhibitor of metalloproteinases (TIMP) as potential biomarkers in a number of different diseases including cancer, cardiovascular disease, chronic lung disease and diabetes. TIMPs may be especially relevant as cancer biomarkers because they inhibit the activity of matrix metalloproteinases (MMPs), which play a role in tumor invasion and metastasis. Many studies […]

By |December 2nd, 2015|Breast Cancer|0 Comments

Biomarker Basics

As this blog focuses on reviewing scientific papers describing biomarker discovery, validation and clinical use, we felt that it was time to pause and review some biomarker basics.

What is a biomarker? A biomarker can be objectively measured to assess a biologic process, a disease process, or a response to a treatment or lifestyle change.1 Almost […]