Metabolic Disorder

Biomarker Basics

As this blog focuses on reviewing scientific papers describing biomarker discovery, validation and clinical use, we felt that it was time to pause and review some biomarker basics.

What is a biomarker? A biomarker can be objectively measured to assess a biologic process, a disease process, or a response to a treatment or lifestyle change.1 Almost […]

Metabolic Syndrome: Proteomic Changes in Pigs Fed a Cafeteria Diet vs. a Mediterranean Diet

A team of Dutch researchers, led by Marinus F.W. te Pas,1 tested whether pigs can serve as a model for early stage metabolic syndrome biomarkers. Pigs share many metabolic similarities with humans and offer several advantages for studies focusing on dietary effects. Not only can metabolic syndrome be experimentally induced in pigs and a more […]

By |November 1st, 2015|Metabolic Disorder|0 Comments

Metabolic Precursors of Hypertension on the Road to Cardiovascular Disease

A team of Korean scientists led by Minjoo Kim1 used ultra-high performance liquid chromatography coupled with mass spectrometry and multivariate data analysis to identify prehypertension-associated plasma metabolites. Prehypertension, defined by blood pressure measurements of 120-139 mmHg (systolic) and 80-89 mmHg (diastolic), can precede hypertension and atherosclerosis on the road to cardiovascular disease.

The researchers identified 53 […]

By |September 16th, 2015|Metabolic Disorder|0 Comments

High Saturated Fats Alter the Proteome of People with Metabolic Syndrome

Rangel-Zuniga’s recent research publication,1 which describes proteomic changes resulting from dietary lipids, may be valuable to anyone with a scientific – or even personal – interest in metabolic syndrome.

Rangel-Zunigal and his research team wanted to determine whether diets that vary in the quantity and quality of fatty acids would influence the proteome (the set of […]

By |August 27th, 2015|Metabolic Disorder|0 Comments

Metabolic Syndrome: Understanding the Risk Factors

The risk factors associated with metabolic syndrome are dyslipidemia, hypertension, central obesity and hyperglycemia.1 But what exactly is each of these conditions? How are they defined? And what is their role in metabolic syndrome?
Central Obesity
Central obesity has an ethnic and country specific definition, but it generally refers to increased waist circumference due to fat deposition […]

By |August 3rd, 2015|Metabolic Disorder|0 Comments

What is Metabolic Syndrome?

Metabolic syndrome is not, in and of itself, a disease. It is a term that was initially coined by the World Health Organization (WHO) in the late 1990s to identify people at a greater risk of developing cardiovascular disease (CVD).1  In essence, metabolic syndrome refers to a cluster of diseases that confer a cumulative risk […]

By |July 17th, 2015|Metabolic Disorder|0 Comments