Monthly Archives: November 2015

Biomarker Basics

As this blog focuses on reviewing scientific papers describing biomarker discovery, validation and clinical use, we felt that it was time to pause and review some biomarker basics.

What is a biomarker? A biomarker can be objectively measured to assess a biologic process, a disease process, or a response to a treatment or lifestyle change.1 Almost […]

Do You Know Your Oxidative Stress Balance Score?

Oxidative stress results from an imbalance between oxidants and antioxidants that leads to cellular damage. Oxidative stress is complex, involving both intrinsic and extrinsic factors. It is closely tied to inflammation and contributes to aging, cancer and cardiovascular disease. As mentioned in a previous blog post Redox Redux, oxidative stress and damage are challenging to […]

By |November 18th, 2015|Inflammation|0 Comments

Redox Redux: Oxidative Stress and Biomarkers

Oxidative redox processes can cause human disease. During periods of oxidative stress, reactive oxygen and nitrogen species can structurally alter and impair the function of cellular proteins, lipids and DNA. While these highly reactive and short-lived species are hard to measure directly, researchers monitor them through the footprints they leave behind on certain proteins. Identifying […]

By |November 11th, 2015|Breast Cancer, Inflammation|0 Comments

Metabolic Syndrome: Proteomic Changes in Pigs Fed a Cafeteria Diet vs. a Mediterranean Diet

A team of Dutch researchers, led by Marinus F.W. te Pas,1 tested whether pigs can serve as a model for early stage metabolic syndrome biomarkers. Pigs share many metabolic similarities with humans and offer several advantages for studies focusing on dietary effects. Not only can metabolic syndrome be experimentally induced in pigs and a more […]

By |November 1st, 2015|Metabolic Disorder|0 Comments