Monthly Archives: July 2015

Tissue-Based Diagnostic Tests for HER-2 in Breast Cancer

There are currently three tissue-based diagnostics available to test for HER-2 positive breast cancer:

Immunohistochemistry
Inform Dual In Situ Hybridization
Fluorescence In Situ Hybridization

Pathologists use HER-2 tissue tests to detect a protein called HER-2 (“human epidermal growth factor receptor 2”) that is found in certain types of cancer cells.   Alternatively, some tests are designed to detect the HER-2 […]

By |July 27th, 2015|Breast Cancer|0 Comments

What is Metabolic Syndrome?

Metabolic syndrome is not, in and of itself, a disease. It is a term that was initially coined by the World Health Organization (WHO) in the late 1990s to identify people at a greater risk of developing cardiovascular disease (CVD).1  In essence, metabolic syndrome refers to a cluster of diseases that confer a cumulative risk […]

By |July 17th, 2015|Metabolic Disorder|0 Comments

The Importance of HER-2 Testing During Treatment for Breast Cancer

The more HER-2 genes a breast cancer cell has, the more HER-2 protein that cell will produce and the faster the cancer will grow. If a breast cancer patient is diagnosed with a positive HER-2 status, they typically will receive a targeted treatment such as Herceptin or Tykerb.1

However, even after treatment begins, HER-2 status remains […]

By |July 13th, 2015|Breast Cancer|0 Comments

New Mass Spectrometry Immunoassay Detects Insulin and Analogues

Insulin is a peptide hormone produced by the beta cells of the pancreas. It is secreted into the plasma to promote efficient glucose utilization and to maintain glucose homeostasis. Measuring the levels of insulin can be challenging as it is present in very small quantities (sub ng/ml) in a complex biological matrix, so must be […]

By |July 3rd, 2015|Diabetes|0 Comments

Breast Cancer CSI: Suspects and Therapeutic Targets Identified

Molecular biology is like criminology. Experts study the crime scene to identify a suspect, and then investigate all known associates. They try to determine where suspects and associates interact and understand the nature of their relationship. Csiszar and colleagues1 investigated the players and interactions involved in breast cancer metastasis, specifically the epithelial-to-mesenchymal transition (EMT). In […]

By |July 3rd, 2015|Breast Cancer|0 Comments

Monitoring Serum HER2 for Breast Cancer Prognosis

HER2 is one of a handful of breast cancer biomarkers used for clinical decision making. Breast cancer patients whose tumor tissue samples have a positive HER2 status may be offered anti-HER2 targeted therapies such as Trastuzumab or Lapatinib. The American Society of Clinical Oncology (ASCO) and College of American Pathologists (CAP) released updated guidelines on […]

By |July 3rd, 2015|Breast Cancer|0 Comments

Uncovering the Complex Origins of Diabetes

According to the 2014 National Diabetes Statistics Report published by the US Center for Disease Control and Prevention1, an estimated 29.1 million Americans, or 9.3% of the US population have diabetes. This number will continue increasing in the next few decades. Once simplistically viewed as a disease of impaired glucose metabolism, diabetes is now recognized […]

By |July 3rd, 2015|Diabetes|0 Comments