1501, 2016

A Potential New Biomarker Panel for Lung Cancer Diagnosis

Lung cancer diagnosis typically involves a physical examination, imaging and procedures such as a bronchoscopy or a biopsy to obtain samples. Pathologists analyze tumor specimens to determine cancer histology and conduct molecular testing to identify […]

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101, 2016

Combining Biomarkers with Risk Factors to Predict Coronary Artery Disease

Although cardiovascular risk factors such as increased age, hypertension, diabetes mellitus, smoking and dyslipidemia are well known, they do not accurately predict the risk of coronary artery disease. A Korean research group led by Sunsoo […]

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2012, 2015

uPA and PAI-1 Breast Cancer Biomarkers and Clinical Utility: When Strong Evidence is Not Enough

Multiple studies have demonstrated that urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have clinical utility as breast cancer biomarkers. uPA is an extracellular matrix-degrading protease involved in cancer invasion and metastasis. PAI-1 is […]

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912, 2015

What is Triple Negative Breast Cancer and What does it Mean for Treatment?

Breast cancer is a disease that has many different subtypes, each with varying treatments and outcomes. The breast cancer subtypes are differentiated by the type of receptors expressed on the surface of the tumor cells. […]

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212, 2015

TIMP-1 and HER2 ECD as Biomarkers for Breast Cancer

Researchers are currently investigating tissue inhibitor of metalloproteinases (TIMP) as potential biomarkers in a number of different diseases including cancer, cardiovascular disease, chronic lung disease and diabetes. TIMPs may be especially relevant as cancer biomarkers […]

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2511, 2015

Biomarker Basics

As this blog focuses on reviewing scientific papers describing biomarker discovery, validation and clinical use, we felt that it was time to pause and review some biomarker basics.

What is a biomarker? A biomarker can be […]

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